Not sure if you can talk about this yet.
How are you handling the above, coexisting with biological life?
Is AI subservient? Master of? Indifferent? Enemy? Or something else in your setting?
I find this a really really hard question to answer to make a game setting fun.
http://www.sfwriter.com/precarn.htm
http://www.popbioethics.com/2012/02/why-mass-effect-is-the-most-importan...
Above are a couple of articles about this.